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Phenylketonuria Home Page. Phenylketonuria (PKU) information. PKU isn’t just a diet thing; it’s a brain thing. Best ways to care for your child with PKU. Protect a developing brain from high blood phenylalanine (Phe) levels. PKU can impact how you think, feel, act, and function. High or unstable blood Phe levels can be managed and improved.

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