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List of Top Websites Like Beacon-center.org

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Last updated on Jun 1 2019.
Here are the best websites we found: beacon-center.org • getmessyart.com • menconnect.at • viralgrow.io • 7-ketodheametabolite.blogspot.com • communityfolks.com • sapphireconnection.com • crypto-consultant.org • edwardcarpentercommunity.org.uk

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BEACON | An NSF Center for the Study of Evolution in Action. By: Dr. Wenying Shou - Fred Hutchinson Cancer Research Center Sometimes in science, a seemingly straightforward journey can take an enormous amount of time. Our paper in PLoS Biology (Hart et al., 2019) was one such journey. The question seemed easy enough: for a highly simplified microbial community — a community of two yeast strains engineered to help each other or "cooperate", could we predict how fast the community might grow? If you think that this question is esoteric, it is not. Cooperation is surprisingly common in biology: pathogenic bacteria cooperate with each other to launch infections; microbes in sewage treatment sludge cooperate to break down wastes. The faster a community can grow, the more likely it will survive perturbations or advance to new territories. Ultimately, a quantitative understanding of microbial communities will empower us to control and use communities as, for example, probiotics. One remarkable aspect of this work — the very long and turbulent gestation — is invisible from the data themselves. When responding to journal reviewers' critiques, I had the urge to write down this untold story of scientific discovery. A humble dream The project started when I was a postdoc about 17 years ago. To tie biology with mathematics, I joined a physicist's lab at the Rockefeller University in New York City. I wanted to see how interacting "parts" of a biological system might generate quantitative properties of the system as a "whole". All biological systems consist of parts. For example, an ecological community consists of interacting species, and the human body consists of different cell types. A quantitative understanding of how a biological system works can be very powerful. For example, it could help us predict what would happen if we were to perturb a part. A mathematical model consists of one or more equations. An equation describes how different quantities are linked to each other. For example, how fast population size changes equals how fast new members are added through birth, minus how fast the existing members die. The growth and death rates are examples of model parameters. Back then, people had been modeling biological systems such as ecological communities, gene regulatory networks, and the cell division cycle. Some models matched data beautifully. However, the renowned mathematician and computer scientist John von Neumann once stated "with four parameters I can fit an elephant, and with five I can make him wiggle his trunk." In other words, given enough "free parameters" — parameters one could freely choose rather than being constrained by reality from experimental measurements, a model can be made to fit any data. Although a fitting model can explain data, it does not mean that the model is correct or can predict new data. To avoid the "free parameter" problem, I decided to start with a very simple system. In such a system, I should know exactly how parts interact with each other. I could then write down the equations, know which parameters need to be measured, and measure all parameters. After much deliberation, I decided to engineer a highly simplified cooperative yeast community consisting of two strains, each supplying the other with an essential metabolite. My colleagues and I thought of a lovely name for it: CoSMO — Cooperation that is Synthetic and Mutually Obligatory. Unlike real-life communities where scientists often have trouble counting the number of species, CoSMO has two and only two strains. Unlike real-life communities where species influence each other by releasing many uncharacterized chemicals, in CoSMO each strain releases only one metabolite which is required and consumed by the partner. Moreover in CoSMO, the two strains coexist due to their inter-dependence, and thus I do not need to worry about losing any one of them. Now that I know how the two strains interact with each other, it should in principle be easy to predict community properties, such as how fast the community grows — or community growth rate. Community growth rate primarily depends on two traits of each strain: the metabolite release rate and the amount of metabolite consumed per birth. Thus, modeling community growth rate boils down to measuring four parameters. This is by no means ambitious! Mission aborted I measured all four parameters. I measured the metabolite release and consumption traits of each strain in the absence of its partner. I got rid of the partner so that the released metabolites would accumulate in the test tube for me to measure, instead of being immediately consumed by the partner. However, since the partner was not present, the measurement environment (called the "batch culture" environment) differed from the community environment. For example, to measure metabolite consumption in batch cultures, I would add a high dose of metabolite at the beginning of an experiment. In contrast, in communities, the consumed metabolite is constantly supplied by the partner at a low level. Measuring strain traits in a community-like environment would require a special experimental setup. So, I had to hope that the batch culture environment could approximate the community environment. After measuring the four parameters, I predicted community growth rate. However, my prediction was way off from the experimental results. I was disappointed. In theory, a mathematical model is useful when it fails, because failure suggests that we are still missing important pieces. In reality, I was far from being thrilled by the failure, because too many pieces could be missing, even in a system as simple as CoSMO. For example, the batch culture environment might not approximate the community environment; cells could be evolving… The problem immediately becomes monstrously messy and un-elegant — a devil. Eventually, I aborted the mission. I was forced to ask whether I could explain some other community property — the minimal total cell density required for the community to start to grow. That calculation required measuring more parameters — such as cell growth rates at various metabolite concentrations. I did not have the experimental setup for such measurements, so I gave in to free parameters. I did what was, and is still, commonly done: looking for literature values. The literature values varied over an order of magnitude, so I naturally chose the value that could explain my data. I felt guilty, but comforted myself by noting that at least, the free parameter I chose was not outrageous, and that at least, the fraction of free parameters in my model was far lower than most other models. This reasoning did not exonerate me, but helped to bring a closure to my postdoc project (Shou et al., 2007). Haunted by the devil When I started my lab at the Hutch, I promptly locked up the devil in a closet. I felt caught: on the one hand, grant reviewers kept punishing me because "CoSMO is too simple", yet on the other hand, I could not even understand a very basic property of the community. My modeling failure was indeed humiliating. There was no way I could rephrase the question in an exciting fashion to attract any one, possibly even including myself. My group started working on other more sexy problems, such as how the two cooperating strains might fend off cheaters who consume but do not contribute metabolites (Momeni et al., 2013b; Waite and Shou, 2012). Despite group members' successes, the devil kept haunting me. Babak Momeni, then a postdoctoral fellow in my lab, examined spatial patterning in CoSMO when CoSMO grew on an agarose pad. When we compared patterns predicted by our model versus patterns observed in experiments, they looked similar in a qualitative sense. However, the timing looked very different. This is not surprising given that we do not understand how fast the community grows. Fortunately, dynamics was not the focus of that paper, so we erased all time stamps from our simulations (Momeni et al., 2013a). Devil breaking loose Eventually, the devil of my past failure would not allow me to ignore it any further. Chi-Chun Chen and Jose Pineda, two talented group members, were quantifying metabolite release rates of evolved cells. They wanted to see whether cells could evolve to be more "generous" by releasing more. However, Chi-Chun and Jose were getting highly variable results despite their superb experimental skills. It seemed that we got stuck when the question turned quantitative. We suspected that the variable measurement results could be due to cell traits being highly sensitive to the measurement environment. To enable measurements in a community-like environment, David Skelding — a physicist in the lab — started to build devices called "chemostats". In chemostats, nutrients were supplied at a small dose (in small drops) but frequently (every tens of seconds), mimicking partner strain's slow but constant metabolite release rate. It took David a good year or more to ensure that chemostats worked reliably and precisely (Skelding et al., 2018). Taming the devil When Sam Hart joined my lab as a research technician, he inherited the problems I, Chi-Chun, and Jose had left behind. Initially, Sam continued to quantify strain traits in batch cultures, because after all, chemostat measurements are much harder and are limited by the number of chambers. However, at some point, we realized that without getting our fundamentals on a solid footing, we would be chasing after our tails: If we do not understand the two ancestral strains (i.e. why ancestral strains' traits cannot explain ancestral community's growth rate), there is no point trying to understand evolved strains. By that time, Sam had already invested a year or two. But Sam was unflustered because he understood the importance of asking the right, albeit inconvenient, question. Sam re-measured ancestral strains' metabolite release and consumption traits in David's chemostats. By controlling how slowly metabolites were supplied, Sam could force cells to grow at various slow rates observed in CoSMO. However, chemostats introduced their own devil: because of metabolite limitation, cells from both strains quickly evolved away from their original states while adapting to metabolite limitation. Sam then figured out ways to deal with this new problem. Eventually, Sam discovered that indeed, measurements of metabolite release and consumption traits could differ significantly in chemostats versus in batch cultures. Hanbing Mi, an undergraduate visiting student from China, figured out how to properly measure community growth rate when cells could evolve quickly. Once we took all these into consideration, we solved the puzzle (Hart et al., 2019). But only partially: we still do not understand CoSMO's initial phase of slower growth. Using the same quantification methodology that we have found to be trustworthy, Sam figured out what it means to be "generous" (Hart & Pineda et al., 2019), and which mutants evolved to be more generous (manuscript in preparation). Sam is now a graduate student at the University of Washington. Summary It takes a lot to do careful science. For science to advance, it must stand on a solid foundation. By demonstrating how to properly model a very simple living system, we have helped setting the standard for future modeling of more complex systems such as probiotic communities or infectious diseases. Acknowledgements I am very grateful to my lab members, particularly Sam Hart, Hanbing Mi, Jose Pineda, Chi-Chun Chen, and David Skelding, for doing high-quality work. Hart & Pineda, Chen, Chichun, Green, Robin, Shou W. 2019. Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community. eLife Accepted. Hart SFM, Mi H, Green R, Xie L, Pineda JMB, Momeni B, Shou W. 2019. Uncovering and resolving challenges of quantitative modeling in a simplified community of interacting cells. PLOS Biol 17:e3000135. doi:10.1371/journal.pbio.3000135 Momeni B, Brileya KA, Fields MW, Shou W. 2013a. Strong inter-population cooperation leads to partner intermixing in microbial communities. eLife 2:e00230. doi:10.7554/eLife.00230 Momeni B, Waite AJ, Shou W. 2013b. Spatial self-organization favors heterotypic cooperation over cheating. eLife 2:e00960. doi:10.7554/eLife.00960 Shou W, Ram S, Vilar JM. 2007. Synthetic cooperation in engineered yeast populations. Proc Natl Acad Sci USA 104:1877–1882. doi:10.1073/pnas.0610575104 Skelding D, Hart SF, Vidyasagar T, Pozhitkov AE, Shou W. 2018. Developing a low-cost milliliter-scale chemostat array for precise control of cellular growth. Quant Biol 6:129–141. Waite AJ, Shou W. 2012. Adaptation to a new environment allows cooperators to purge cheaters stochastically. Proc Natl Acad Sci 109:19079–19086. doi:10.1073/pnas.1210190109. evolution, interdisciplinary, biology, computational biology, engineering, evolutionary algorithms, evolutionary computation, evolutionary outreach, education, graduate student, postdoc, research, teaching
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South Kendall Community Church | Welcome!. Welcome to the e-home of South Kendall Community Church! With over 25 different nationalities represented in our church family, we are a diverse mosaic of the South Florida community we love and serve. We have been in our current location since 1994, and continue today to grow in our relationships with each other and we welcome all in the name of Jesus Christ. Our worship services take place mostly in English, but Spanish is frequently spoken in our church.
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The Edward Carpenter Community | For men who love men. The Edward Carpenter Community. Over 30 years of events for men who love men. Non-scene, post-scene community, personal growth, sparkle, trust and friendship.
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Panorama Community Schools. Panorama Community Schools serves students in grades K-12 and is located in Panora, Iowa.
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Conscious Community | Milagro World Center. The Milagro World Center's vision is the miracle of Humanity's Potential Realized. We provide education, events and conscious community space dedicated to profound personal growth.
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Community and Patient Preference Research (CaPPRe) is a world leading expert in eliciting community and patient preferences using advanced choice based measurement. | CaPPRe. CaPPRe is a research group committed to meaningful research leading to better engagement and understanding of community and patient needs.
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"The Pathway to Home Ownership" at Edmonds Community College Tickets, Sat, Sep 8, 2018 at 10:00 AM | Eventbrite. Eventbrite - Community Home Buyer Education Services presents "The Pathway to Home Ownership" at Edmonds Community College - Saturday, September 8, 2018 at Edmonds Community College, Lynnwood, WA. Find event and ticket information.
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Charotar Leuva Patel-Patidar Community - Charotar Samaj of USA. Charotar is a region in Central Gujarat. Sardar Vallabhabhai Patel and population of Patel community makes charotar patel community popular unlike any other community in India. 14Gaam.com offer free matrimonial service, introducing our culture values, Hinduism, Hindu Festivals, Ancestries, community news services, make announcement any many more.
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Spring Valley Mobile Home Community and Apartments. A Family Oriented Manufactured Home Community Spring Valley Mobile Home Community and Apartments is a family oriented community that was built in 1971. The community has 186 lots for manufactured homes and 24 apartments. We are located close to two major highways (I-26 and I-526), close to Northwood Mall, downtown
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LambdaGeneration - The Ultimate Half-Life Community: Half-Life & Valve News, Videos, Mods, Fan Creations and more…. The Ultimate Half-Life Community: Half-Life & Valve News, Videos, Mods, Fan Creations and more...
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Community Develpment Institute. CDI is a national training program endorsed by the Community Development Council (CDC) that promotes the development of community volunteer leaders.
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=ADK= Gaming Community | Online Gaming Forums |. The ADK Gaming Community is one of the largest online gaming communities in the world. We provide community guides, discussions and news for all of the major games!
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SCF : Solano Community Foundation : Your Community Partner. Solano Community Foundation is a qualified 501(c)(3) public charity, established in July of 1996 to serve the charitable needs of Solano County residents. We are an institution of the community and for the community.
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Community and Patient Preference Research (CaPPRe) is a world leading expert in eliciting community and patient preferences using advanced choice based measurement. | CaPPRe. CaPPRe is a research group committed to meaningful research leading to better engagement and understanding of community and patient needs.
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Charotar Leuva Patel-Patidar Community - Charotar Samaj of USA. Charotar is a region in Central Gujarat. Sardar Vallabhabhai Patel and population of Patel community makes charotar patel community popular unlike any other community in India. 14Gaam.com offer free matrimonial service, introducing our culture values, Hinduism, Hindu Festivals, Ancestries, community news services, make announcement any many more.
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Indian Writers Community - TGIWC | National Community. The Great Indian Writer's Community (TGIWC) is an organisation which consists of group of people with a particular purpose. It is a community representing Indian writer's and along with that it also focuses on Educational sector to support and grow you on an individual level.​
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Home of CHOPAS Community Portal and HOA-COA Websites. CHOPAS offers the latest technology in community portal and hoa websites for managed properties.
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Westport Community Schools. Westport Community Schools is a district of three schools from prekindergarten to twelfth grade in Westport, MA.
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People''s Community Bank. Peoples Community Bank is a family of dedicated individuals making a commitment to act as one. We are a family owned and community oriented bank, where customer service is not a department…it is our attitude.
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Nigeria’s biggest Pregnancy, parenting and child care community - Babymigo. Babymigo is the largest and most professional pregnancy, parenting and baby care community that brings together thousands of moms, moms in the same age, same city moms, Mothers with similar interest to share parenting knowledge. Babymigo provides parenting knowledge and parenting questions and answers for parents who are trying to conceive, pregnant mothers and parents with babies ( 0-6 years)
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Community GMC Inc in Wilmington | Serving Kankakee, Joliet & Morris, IL GMC Customers. Community GMC Inc serves Joliet and Kankakee customers with GMC trucks and SUVs in Wilmington, IL. We are your premier dealership and looking forward to seeing you soon!
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Hartford Foundation for Public Giving: CT Community Foundation. The Hartford Foundation for Public Giving works with donors, nonprofits and community leaders to put resources into action for Greater Hartford.
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Racine Community Church | Welcome!. If you haven''t already experienced a service at Community Church, we hope you will consider visiting this weekend. We simply want to meet you, answer your questions, and introduce you to Community Church. Racine Community Church of the Nazarene 8440 Spring Street, Racine, WI 53406 262.886.6606
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Cumberland Multicultural Community Services NSW | Improving the lives of children, families and communities. Granville Multicultural Community Centre offers a variety of community, educational and social activities and services to residents in the local area. We exist to improve the lives of children, famili
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Community Resources for Independent Living - CRIL. Community Resources for Independent Living (CRIL) is a peer-based disability organization that advocates and provides resources for people with disabilities to improve lives and make community fully accessible. CRIL offers Independent living services at no charge to persons with disabilities living in southern and eastern Alameda County.
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Aboriginal Community Elders Services Inc. Aboriginal Community Elders Services Inc (ACES) is a Not-For-Profit Aboriginal community controlled organization.
Alexa Rank
1,000,001
Startseite - Resident Evil Community Forum. Resident Evil, Resident Evil HD, Resident Evil HD Remake, The Evil Within, The Evil Within Forrum, The Evil Within Community, The Evil Within Board, Resident Evil 5, Resident Evil 6, Biohazard 6, Biohazard, Resident Evil Forum, Resident Evil Board, Resident Evil Community, Resident Evil Seite,Resident Evil 2 Demo, Resident Evil Downloads, Resident Evil 3 Demo, Resident Evil Umbrealla Chronicles, Resident Evil Merchanieres 3D, Resident Evil Revelations, Resident Evil Darkside Chronicles, Resident Evil 4, Resident Evil 0, Resident Evil 1, Resident Evil Remake, Resident Evil 2, Resident Evil 5, Zone, Chat, Forum, Merchandise, Gaiden, Outbreak, Dead Aim, Gun Survivor, Code Veronica, Ada Wong, Weskers Report, Wallper, Downloads, Merchandise, Timeline, Raccon City, S.T.A.R.S., Umbrella, T-Virus, G-Virus, Tyrant, Nemesis, Redfield, Valentine, Zombie, Hunter, Licker, Albert, Hunk, Ada, Leon, Kennedy, Ashley, Saddler, Ganados, Verdugo, Gigante, Luis, Krauser, Jack, Birkin, Jill, Chris, Barry, Mansion, Biohazard, Plagas, U3, Cerberus, Trevor, Lisa, Morpheus, Claire, Redfield, Steve, Burnside, Deadly Silence, Salazar, Survival, Horror, Wong, News, Umfrage, Eliminator, Stinger, Prototyrant, Plant, Online, William, Capcom, Shinji, Mikami, Survival, Zero, Fan Stuff, Community,Forum, Seite, Resident Evil Wii, Resident Evil Directors Cut, Sheva, Chris Redfield, Jill Valentine, Albert Wesker, Alamour, Resident Evil PC, Resident Evil 4 PC, Resident Evil 5 PC, Resident Evil 5 PS 3 Demo, Resident Evil 5 Xbox360, Wii, PS 3, PS 2, Gamecube
Alexa Rank
1,000,001
City of Maple Grove Community Center, party room rentals, public swimming pool, Maple MazeGymnasium, Ice Arena. The City of Maple Grove Community Center offers the community a wide variety of services and facilities including party room rentals, public swimming pool, Maple Maze, Membership rates, Town Green, Farmers Market, Birthday parties, Grove Cove Aquatic Center, Gymnasium, Ice Arena, Maple Maze Indoor Playground, room rental, party room rentals, skate park, teen center, group rentals, senior centers, outdoor sand volleyball
Alexa Rank
1,000,001
Westport Community Schools. Westport Community Schools is a district of three schools from prekindergarten to twelfth grade in Westport, MA.
Alexa Rank
1,000,001
Welcome to Vinson Hall Retirement Community - Vinson Hall. Vinson Hall Retirement Community, located in McLean, Va., is a continuing care community, offering a vibrant independent living community as well as assisted living and memory care facilities.
Alexa Rank
1,000,001
Sun Lakes of Arizona Community Website in 85248. Sun Lakes, AZ 85248. A planned community of five country club resort style communities.
Alexa Rank
1,000,001
Watertown Community Foundation: Local Community Development in Massachusetts. Watertown Community Foundation is a public foundation that works for community development and charitable giving in The City of Watertown, Massachusetts.
Alexa Rank
1,000,001
Community Health and Wellness Partners of Logan County | A Federally Qualified Health Center. Community Health & Wellness Partners of Logan County is a community-based and patient-directed organization that serves populations with limited access to healthcare.
Alexa Rank
1,000,001
SAFE COMMUNITY - South Africa Crime Prevention and Community Networking. At SAFE COMMUNITY, our mission is to network the public with SAPS, CPF, service providers and schools through the ultimate safety and security crime fighting network available.
Alexa Rank
1,000,001
LifePoint Community Church at Willow Springs Elementary School | Home. LifePoint Community Church at Willow Spring, North Carolina, We are a local Community Church that has a desire to point people to life in Jesus Christ. We are striving to serving the local community and School to show them the love of Jesus Christ. Our mission is to “To point people to life in Jesus Christ so that they become mature followers of Christ.” In John 10:10 Jesus said, “I have come that they may have life, and that they may have it more abundantly.”
Alexa Rank
1,000,001
Easton Community Choir - Easton Community Choir. Easton Community Choir, Bristol. Mixed acappella choir meeting in Tuesday evenings at Easton Community Centre, Bristol. Forest of Dean Singing Camp.
Alexa Rank
1,000,001
City of Maple Grove Community Center, party room rentals, public swimming pool, Maple MazeGymnasium, Ice Arena. The City of Maple Grove Community Center offers the community a wide variety of services and facilities including party room rentals, public swimming pool, Maple Maze, Membership rates, Town Green, Farmers Market, Birthday parties, Grove Cove Aquatic Center, Gymnasium, Ice Arena, Maple Maze Indoor Playground, room rental, party room rentals, skate park, teen center, group rentals, senior centers, outdoor sand volleyball
Alexa Rank
1,000,001
Belleville and Quinte West Community Health Centre | Health care and support services for people in our community. At the Belleville and Quinte West Community Health Centre, we offer a wide range of services and programs to improve the health of our clients and the community as a whole. The Centre has sites in Belleville and Quinte West. Our services and programs include primary health care, health promotion, and community capacity building. They are open to the community, they are confidential and they are free of charge.
Alexa Rank
1,000,001
Community Council Website - get a free website for your Community Council. Community Council websites from Spanglefish are Free. Spanglefish''s free system provides all the functionality you will need for your Community Council website.
Alexa Rank
1,000,001
Watertown Community Foundation: Local Community Development in Massachusetts. Watertown Community Foundation is a public foundation that works for community development and charitable giving in The City of Watertown, Massachusetts.
Alexa Rank
1,000,001
Harbour's Edge | Senior Living Community in Delray Beach, Florida. Independent thinkers preferring a continuing care retirement community that understands the vital, purpose-driven senior’s unique perspective, like what they find at Harbour’s Edge.
Alexa Rank
1,000,001
Dishchii''bikoh Community School. Dishchii''bikoh Community School is located in Cibecue, AZ and is a district that caters to kindergarten through twelfth grade.
Alexa Rank
1,000,001
Joyful Voice Community Choir | Vancouver, BC, Canada. Joyful Voice Community Choir - Vancouver
Alexa Rank
1,000,001
People''s Community Bank. Peoples Community Bank is a family of dedicated individuals making a commitment to act as one. We are a family owned and community oriented bank, where customer service is not a department…it is our attitude.
Alexa Rank
1,000,001
Little Bird Community Acupuncture. Little Bird Community Acupuncture is a community acupuncture clinic in Adams Morgan in Washington, DC. Our mission is to provide high quality acupuncture treatment at affordable rates in a supportive community setting. Treatment rates are on a sliding scale of $20-$40.
Alexa Rank
1,000,001
Community Association Property Management, Palm Beach Co., Florida. Community Association Property Management, Palm Beach Co., Florida
Alexa Rank
1,000,001
Albion Hills Community Farm. Albion Hills Community Farm -
Alexa Rank
1,000,001
Community Health and Wellness Partners of Logan County | A Federally Qualified Health Center. Community Health & Wellness Partners of Logan County is a community-based and patient-directed organization that serves populations with limited access to healthcare.
Alexa Rank
1,000,001
LIV Condominium Community Management | Calgary Alberta Canada. LIV Condominium Community Management is Calgary's leading condominium community management firm, specializing in condominium, townhouse, apartment and condominium community management services.
Alexa Rank
1,000,001
Seamer Village Community Website - Seamer, near Stokesley - Seamer, Middlesbrough, Cleveland - Seamer Hambleton. Seamer Village Community Website - News and events in Seamer - Seamer, near Stokesley - Seamer, Middlesbrough, Cleveland - Seamer Hambleton
Alexa Rank
1,000,001
Home - Community Listing Service. Home page - Community Listing Service - select province, state, city or community. Community Listing Service -- your online website directory for businesses, services, and events in your community. Advertise your business / service/ event -- using this
Alexa Rank
1,000,001
The RavenCoin Community Forum. Welcome to the RavenCoin community forum, here you can find all necessary information regarding RavenCoin, and news, updates, software, and more!
Alexa Rank
1,000,001