Flu Shots | Fluzone® High-Dose Quadrivalent Influenza Vaccine and Flublok® Quadrivalent Influenza Vaccine. As you get older, your immune system may get weaker, making you more susceptible to the flu. Fluzone High-Dose Quadrivalent is a flu vaccine specifically formulated for adults 65+, while Flubok Quadrivalent is a flu vaccine for adults 18+. Learn more.